Senators voted 57-43 late Tuesday to reject the plan in the first vote on an amendment to the bill. Those voting “no” included nine defecting Republicans.

The amendment vote portends a rough road ahead for GOP efforts to advance some form of ObamaCare replacement, even after the Senate narrowly revived the core bill in a dramatic test vote Tuesday afternoon. 

Senators planned to vote Wednesday on another Republican amendment repealing much of the health law and giving Congress two years to come up with a replacement. A combination of solid Democratic opposition and Republicans unwilling to tear down the law without a replacement in hand were expected to defeat that plan as well.

In the failed vote Tuesday night, GOP foes…